Select the correct combination of mathematical signs to sequentially replace the * signs and balance the given equation.
45 * 86 * 23 * 36 * 18 * 2021

A

$$\times, +, −, \div, =$$

B

$$+, −, \times, \div, =$$

C

$$−, \times, +, \div, =$$

D

$$+, \times, −, \div, =$$